The Doctor's Farmacy With Mark Hyman, M.d.

What if your fatigue, weight gain, hormone imbalances, and brain fog all traced back to a silent disease that affects 1 in 3 people—and you didn’t even know you had it? In today’s episode, I’m joined by Dr. Elizabeth Boham and Dr. Yousef Elyaman to talk about a condition that’s quietly becoming one of the biggest threats to our health: fatty liver disease—now renamed Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). It’s not just a liver issue. It’s deeply connected to heart disease, cancer, infertility, type 2 diabetes, dementia, and even hormone dysfunction. The most alarming part is it’s often missed in traditional medicine because there’s no easy drug to prescribe. We break down: The real root causes—from sugar and starch overload to gut imbalances, toxins, alcohol, and chronic inflammation The surprising early warning signs your body might be giving you Why standard labs often miss it, and the tests you actually need The step-by-step functional medicine approach to reverse fatty live

We’re overfed, but undernourished. Despite having access to more food than ever, most people are walking around with nutrient deficiencies that could be accelerating aging, increasing disease risk, and depleting energy levels. That’s why I sat down with Dr. Rhonda Patrick, a leading expert in nutritional science and aging, to break down what we’re missing—and why it matters. In this episode of The Dr. Hyman Show, we explore: Why nearly 70% of Americans are deficient in vitamin D and what that means for longevity. The overlooked role of magnesium in metabolism, blood sugar, and brain function. Why our food system leaves us malnourished—even if we eat a “healthy” diet. The best way to assess and correct micronutrient imbalances for optimal health. Your body can’t function properly without the right nutrients. This episode will show you how to fill the gaps and take control of your health. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevi

Fertility challenges are increasingly linked to lifestyle and environmental factors that go far beyond reproductive organs. Emerging science reveals that metabolic health, inflammation, diet, and exposure to environmental toxins all play a profound role in hormonal balance, egg and sperm quality, and even early embryo development. Key drivers of dysfunction—such as ultra-processed food, insulin resistance, gut imbalances, and mitochondrial damage—are rarely addressed in conventional fertility care, despite their deep impact. Paying attention to these overlooked root causes offers not only a powerful path to improving fertility but also the foundation for lifelong health in both parents and their future children. In this episode, I discuss, along with Kelly LeVeque, what we can do to improve our fertility, which ultimately impacts the future health of our children. Kelly LeVeque is a holistic nutritionist, celebrity health coach, the best-selling author of Body Love and Body Love Every Day, and most importan

What if the key to aging well had been hiding in plain sight—inside our cells, our food, and even… dolphins? That’s exactly what Stephanie Venn-Watson, DVM, a veterinary epidemiologist, discovered while studying dolphins in the U.S. Navy’s marine mammal program. She found that some dolphins were aging significantly slower than others, leading to the discovery of C15:0—a newly recognized essential fatty acid that supports cellular health, fights inflammation, and may even slow the aging process. In this episode of The Dr. Hyman Show, we dive into: How studying dolphins led to the discovery of C15:0 as the first essential fatty acid found in 90 years. Why a deficiency in this nutrient could be accelerating aging and chronic disease. How C15:0 strengthens cell membranes, reduces inflammation, and promotes longevity. The connection between diet, metabolic health, and optimal aging. What you can do to ensure you’re getting enough of this essential fatty acid. This groundbreaking discovery could change how we

The connection between mental health and metabolic health is far deeper than once believed, with growing evidence showing a powerful, bidirectional relationship. Inflammation, poor diet, and gut dysfunction are now recognized as key drivers of both physical and psychological illness—often hiding in plain sight. By addressing root causes such as blood sugar imbalances, nutritional deficiencies, and microbiome disruption, many chronic mental health conditions can improve or even resolve. This emerging science challenges the traditional separation of mind and body, pointing instead to an integrated approach where healing the body becomes essential for healing the brain. Recognizing this link is crucial in shifting the future of mental health care. In this episode, I discuss, along with Dr. Chris Palmer and Dr. Shebani Sethi, why our diet is so closely related to the state of our mental health. Dr. Chris Palmer is a psychiatrist and researcher working at the interface of metabolism and mental health. He is the Di

You probably know Ian Somerhalder from The Vampire Diaries or Lost, but these days, he’s on a mission far bigger than Hollywood. Ian has dedicated his time and platform to tackling some of the most pressing issues of our time—our broken food system, soil depletion, and the health crisis caused by industrial agriculture. In this episode of The Dr. Hyman Show, we explore: How Ian’s passion for regenerative agriculture was shaped by his childhood and family history. The alarming impact of pesticides on human health and the environment. Why farmers are stuck in a toxic cycle—and how regenerative farming offers a way out. How shifting just 10% of U.S. farmland to regenerative practices could transform our health and economy. The powerful connection between soil health, gut health, and disease prevention. Ian’s journey proves that real change starts with what’s on our plates. Don’t miss this inspiring conversation. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. H

The pervasive presence of microplastics and environmental toxins in our daily lives poses a growing threat to human health, with impacts ranging from hormonal disruption and metabolic dysfunction to immune system compromise and chronic inflammation. These contaminants, found in food packaging, water supplies, personal care products, and even the air we breathe, accumulate in the body and contribute to the rise in chronic diseases such as obesity, diabetes, cancer, and autoimmune conditions. Understanding their far-reaching effects is essential, but the good news is that the body has powerful detoxification mechanisms that, when properly supported through dietary choices, lifestyle adjustments, and targeted supplementation, can help mitigate their damage.  In this episode, I discuss, along with toxin-expert Dr. Joseph Pizzorno, why we need to take action to reduce toxin exposures, reverse existing damage, and build a foundation for long-term well-being. Dr. Joseph Pizzorno is a transformational leader in medic

What if I told you life insurance companies can predict, almost to the month, when you’re going to die? That’s exactly what Gary Brecka, a human biologist and former mortality expert, used to do—until he uncovered something shocking. After years of analyzing blood work and medical records, he realized that the biggest predictors of disease and early death aren’t genetic—they’re modifiable. Now, he’s using that knowledge to help people optimize their health and extend their lifespan. In this episode of The Dr. Hyman Show, we discuss: How insurance companies use hidden health data to predict life expectancy with stunning accuracy. The biggest factors that shorten lifespan—and why most of them are within our control. Why vitamin deficiencies, especially vitamin D, are quietly fueling chronic disease. How the right biohacking tools, like red light therapy and oxygen optimization, can reverse aging. What you can do today to take control of your health and longevity. This conversation will change the way you

Our immune system operates like a finely tuned symphony, yet many of us find ourselves out of harmony, vulnerable to persistent infections, autoimmune conditions, and chronic disease. Rather than merely suppressing symptoms, a Functional Medicine approach seeks to identify and address the underlying disruptions driving immune imbalance. Central to this dysfunction is compromised gut health, which undermines immune regulation, while mitochondrial impairment and chronic inflammation further erode the body's capacity for resilience and repair. By restoring balance at the root level, we can cultivate a more robust and adaptive immune system. In this episode, I discuss, along with Dr. Elroy Vojdani and Dr. Leonard Calabrese, how cleaning up our diets, improving gut health, removing toxins, and decreasing stress can do wonders for our immune systems. Dr. Elroy Vojdani is a pioneer in the field of functional medicine and research and is the founder of Regenera Medical, a concierge functional medicine practice in Los

The modern food industry is built for profit, not health. Ultra-processed foods dominate grocery shelves, fueling the epidemic of obesity, diabetes, and chronic disease. But how did we get here? And what can we do to fix it? In this episode of The Dr. Hyman Show, I sit down with Michael Pollan, award-winning journalist and food activist, to break down the hidden forces shaping our food system and the urgent need for change. In this powerful conversation, you’ll discover: How a handful of corporations control our entire food supply—and why that’s a problem. The shocking truth about ultra-processed foods and how they’re engineered to keep you hooked. Why our food system collapsed during the pandemic and what it revealed about its fragility. How food companies quietly buy up health brands and use misleading labels to keep consumers in the dark. The role of policy and lobbying in keeping unhealthy food cheap and widely available. Make sure to tune in—this is a conversation every American needs to hear. Vi

With rates of Alzheimer’s and dementia rising steeply, especially among women, the conventional pharmaceutical model has largely failed in treating the brain. Functional Medicine takes a different systems-based, personalized approach—focusing on inflammation, metabolic health, and environmental exposures—which offers real hope for prevention and even reversal of cognitive decline. In this episode, I discuss, along with Dr. Heather Sandison, Dr. David Perlmutter, and Maria Shriver, why it is possible to reverse cognitive decline and the cutting-edge science of brain health and Alzheimer’s prevention. Dr. Heather Sandison is the The New York Times bestselling author of Reversing Alzheimer’s The New Toolkit to Improve Cognition and Protect Brain Health. As a renowned naturopathic doctor specializing in neurocognitive medicine, she’s the founder of Solcere Health Clinic, San Diego’s premier brain optimization clinic, and Marama, a residential program turning memory care into memory recovery. Dr. Sandison has dedi

Dementia rates are skyrocketing, and cognitive decline is a growing concern. But what if you could actually grow a new brain? In this episode of The Dr. Hyman Show, I sit down with Alberto Villoldo, PhD, a medical anthropologist and shamanic healer (and author of Grow a New Brain), to explore the powerful intersection of ancient wisdom and cutting-edge neuroscience. In this eye-opening conversation, you’ll discover: The Amazonian secret to protecting the brain from dementia and cognitive decline. How certain plant compounds can activate your body’s natural detox and repair systems. The surprising role of gut health in brain regeneration—and how to reset your microbiome. Why serotonin depletion is wreaking havoc on mental health and how to restore balance. How shamanic healing and modern science align to create lasting cognitive health. Tune in to learn how you can take control of your brain health and unlock the potential for true regeneration. View Show Notes From This Episode Get Free Weekly Health T

There is a significant impact of food on brain health and overall well-being, with great importance placed on nutrient-dense, anti-inflammatory foods. Unfortunately, nutrient levels of modern crops are declining, but regenerative agriculture is helping to restore food quality. Specific brain-boosting foods such as leafy greens, small cold-water fish, and polyphenol-rich plants have an ability to reduce neuroinflammation, protect against cognitive decline, and enhance mental clarity. And, ultimately, identifying whole food sources of essential nutrients will support your entire body. In this episode, I discuss, along with Dr. Jeff Bland and Dr. William Li, practical tips on choosing the most nutrient-dense foods and how to harness their benefits for overall health. Dr. Jeff Bland is the founder of Big Bold Health, a company on a mission to transform the way people think about one of nature’s greatest innovations—the immune system. Through Big Bold Health, Dr. Bland is advocating for the power of Immuno-Rejuven

Friendship isn’t just a feel-good concept—it’s essential for your health, happiness, and longevity. In this episode of The Doctor’s Farmacy, I sit down with world-renowned author and leadership expert Simon Sinek to explore the science and psychology of friendship—why we need it, how it impacts our biology, and what it takes to build deep, meaningful relationships in an increasingly disconnected world. In this fascinating conversation, we discuss: The surprising link between friendship and physical health—how loneliness drives inflammation, chronic disease, and even early death. Why your five closest friends determine your habits, health, and overall well-being. The social contagion effect—how behaviors like diet, exercise, and even emotions spread through friend groups. Why food, fitness, and lifestyle interventions won’t work unless we also address social health. The biggest friendship mistakes people make—and how to fix them. The missing conversation in longevity research—why friendship might be t

The rise in obesity and chronic disease over the years is alarming. Rather than genetics, it can be attributed to environmental and dietary changes, emphasizing the role of food quality over quantity. And while GLP-1 agonists like Ozempic may show some promise in addressing metabolic dysfunction, concerns about long-term effects, muscle loss, and cost highlight the need for a more nuanced approach. Ultimately, a holistic strategy that includes diet, lifestyle, and personalized interventions is essential for sustainable health improvements. In this episode I discuss, along with Dr. Tyna Moore and Calley Means, the complexity of obesity, moving beyond the simplistic "calories in, calories out" model to focus on factors like insulin resistance, ultra-processed foods, and metabolic dysfunction. With nearly three decades experience in the medical world, Dr Tyna Moore is a leading expert in holistic regenerative medicine and resilient, metabolic health. Traditionally and alternatively trained in science and medicin

What if instead of managing diabetes with drugs, we focused on reversing it? In this episode of The Dr. Hyman Show, I sit down with Sami Inkinen, CEO and co-founder of Virta Health, and Dr. Greeshma Shetty, a board-certified endocrinologist, to discuss an approach that’s transforming how we treat metabolic disease. They share groundbreaking research and real-world results that prove type 2 diabetes isn’t a lifelong sentence—it can be reversed with the right nutritional and care model. In this conversation, you’ll learn: Why mainstream medicine still treats type 2 diabetes as a progressive disease—even though science shows it’s reversible. How Virta Health is using a combination of nutritional therapy and continuous remote care to achieve Ozempic-level results, without the drugs. The critical role of personalized dietary interventions in reversing metabolic dysfunction. How a high-touch, tech-driven approach to patient care is leading to long-term success. The real cost of diabetes—not just for individual

Ultra-processed foods (UPFs) are identified as the leading cause of preventable death globally. These foods are chemically altered, stripped of their natural structures, and filled with additives, sugars, unhealthy fats, and preservatives, resulting in products that offer little to no nutritional benefit while contributing significantly to chronic disease. In this episode, I talk with Vani Hari and Dr. Shebani Sethi about why ultra-processed foods are not just a health risk—they are a public health crisis. Vani Hari is the food activist behind FoodBabe.com, a NY Times best-selling author of 4 books, founder of the organic products brand Truvani, and was named one of the “Most Influential People on the Internet” by Time magazine. Hari’s viral testimony before the US Senate sparked a massive movement to stop American food companies from poisoning their own citizens with ingredients they don’t use in other countries. Hari founded Food Babe to spread information about what is really in the American food supply. S

We all know sleep is important, but most of us don’t realize just how much it shapes our health—from metabolism and heart function to emotional well-being and even social connections. In this episode of The Dr. Hyman Show, I sit down with world-renowned sleep expert Matthew Walker, PhD, to uncover the science behind why sleep is one of the most powerful (and overlooked) tools for longevity. In this fascinating conversation, we discuss: Why Dr. Walker sees sleep as the foundation of good health and how it enhances the benefits of diet and exercise. The dramatic effects of even mild sleep deprivation on cognitive function and emotional health. How poor sleep can disrupt blood sugar regulation and increase the risk of chronic disease. The science behind deep sleep and its role in memory, learning, and brain detoxification. Simple, science-backed strategies to improve your sleep quality starting tonight. If you’ve ever struggled with sleep—or just want to optimize your health—this is an episode you won’t w

Highly processed vegetable oils, derived from seeds and beans, have become a dominant part of modern diets despite significant health concerns. Historical biases in nutrition science, influenced by the vegetable oil industry, have promoted these oils despite evidence from controlled studies showing negative health outcomes. These oils are unstable, prone to oxidation, and can create toxic byproducts, particularly when exposed to heat, contributing to inflammation and chronic diseases. Although they can lower LDL cholesterol, studies have shown that this reduction does not necessarily improve heart health and may increase risks for other conditions like cancer. In contrast, traditional fats like extra virgin olive oil and omega-3-rich foods offer more stability and health benefits, emphasizing the need for a balanced, minimally processed approach to dietary fats. In this episode, I talk with Nina Teicholz and Max Lugavere to explore the health impacts of different types of fats and oils, debunking misconceptio

Have you ever wondered if cholesterol-lowering statins are as effective as they claim? In this episode, Dr. Mark Hyman and Dr. Aseem Malhotra reveal the truth about these medications and the pharmaceutical industry’s influence on your health. Discover why lifestyle changes like diet and exercise can be more powerful than pills, and how misleading studies have shaped what we believe about heart health. In this episode, we discuss: Big pharma’s influence on medical research The benefits, drawbacks, and misuse of statins The Role of Insulin Resistance in Heart Disease The Importance of Lifestyle Over Medication The Impact of Meditation on Heart Disease View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevity Journal This episode is brought to you by BonCharge, Timeline, Paleovalley, and AirDoctor. Order BON CHARGE’s Max Red Light Therapy device today and get 15% off. Visit BonCharge.com and use code DRMARK for 15% off. Support essential mitochond