The Doctor's Farmacy With Mark Hyman, M.d.

Most health and fitness advice for women is based on research done in men. That’s something we need to rethink. On this episode of The Dr. Hyman Show, I sit down with Dr. Stacy Sims, an exercise physiologist and leading researcher in women’s health. Her work has focused on how female physiology actually changes over time—and how training and nutrition need to change with it. Watch the full conversation on YouTube, or listen wherever you get your podcasts. We explore: • Why eating less and doing more cardio can make fat loss harder • What actually changes in your metabolism in your 30s and 40s • How to train for strength—and why it matters for long-term health • Why most workouts aren’t building muscle (and what to do instead) • How to eat and time protein to support recovery, energy, and better sleep A lot of the advice women have been given doesn’t account for how the body actually changes. Adjusting how you train and eat can make a meaningful difference in your energy, strength, and long-term healt

Autoimmune disease is often treated as something random, lifelong, and out of your control. But what if it’s not your body malfunctioning—what if it’s your immune system responding exactly the way it’s designed to, to something it sees as a threat? When you understand what’s driving that response, everything changes. Here’s what I cover in today’s episode: • The 5 key drivers—food, toxins, gut health, infections, and stress—and how they disrupt the immune system • Why diet is one of the most powerful levers for turning inflammation on or off every single day • The connection between leaky gut, the microbiome, and immune dysfunction • A practical, functional medicine framework to start reducing symptoms and addressing the condition at the root Autoimmune disease isn’t random—it’s the result of cumulative inputs over time. When you begin to change those inputs, you can shift your biology, calm the immune system, and change the trajectory of your health. Visit ⁠functionhealth.com for 160+ lab tests at just $3

We tend to think of heart disease, cancer, and Alzheimer’s as separate problems. But what if they all stem from the same underlying process? On this episode of The Dr. Hyman Show, I sit down with Dr. Eric Verdin, whose research, including work on compounds like urolithin A, is helping reshape how we think about aging and long-term health. We explore why aging may be the biggest driver of chronic disease and what that means for how you approach your health. Watch the full conversation on YouTube, or listen wherever you get your podcasts. We unpack: • How your immune system becomes both overactive and less effective over time • What chronic inflammation is doing inside your body and how to start bringing it back into balance • Why cellular energy and mitochondrial health are key to repair and recovery • How your microbiome shapes inflammation, immunity, and long-term health • The daily habits that impact longevity most and where people get it wrong This conversation reflects a shift in how we think abo

Migraines aren’t just headaches and if you’ve ever had one, you know how debilitating they can be. But they’re not random, and they’re not just genetic. Migraines are a signal that something deeper is out of balance in your body and if you only treat the symptoms, you miss the real opportunity to prevent them. In this episode, I break down what’s really driving migraines, including: • The root causes most people miss—from inflammation and blood sugar swings to hormones, gut health, and nutrient deficiencies • Why migraines are a full-body neurological event, not just a head issue, and what that means for treatment • How your cycle, stress levels, and nervous system can lower your threshold and make migraines more likely • A functional medicine approach to prevention—simple shifts in diet, lifestyle, and nutrients that can reduce frequency and severity Migraines don’t come out of nowhere—they happen when your body hits a threshold. When you lower the load and support your biology, you don’t just manage migra

It’s easy to think of mental health as something happening only in the brain. But more and more, we’re seeing how closely it’s tied to what’s going on in the gut. Today, I’m joined again by Dr. William Li, a New York Times bestselling author. We discuss his latest book, Eat to Beat Your Diet, and how food, inflammation, and microbiome shape the way we think and feel. Watch the full conversation on YouTube, or listen wherever you get your podcasts - https://youtu.be/rY0OE-1blL0 In this conversation we discuss: • What if your anxiety or brain fog is actually a signal coming from your gut • Why gut health may be the missing piece in how we think about mental health • How everyday foods can either fuel inflammation or help calm your system • The compounds in real food that quietly support memory, mood, and mental clarity • Simple shifts that can help reset your system and support how you feel day to day Mental health isn’t separate from the rest of the body. The more we understand that, the more it shift

Most parents are doing their best but the modern food environment is working against them. Between ultra-processed foods, constant marketing, and confusing nutrition advice, it’s easy to feel overwhelmed. But what your child eats doesn’t just affect their growth—it shapes their brain, immune system, metabolism, and long-term health. In this episode, we break down what actually matters and how to approach it without perfection or guilt. Here’s what every parent needs to know: • The foundational nutrition principles that matter most for kids (and why blood sugar stability plays central role) • Whether kids actually need supplements and the most common nutrient deficiencies to watch for • How to strengthen your child’s immune system through food, gut health, sleep, and daily habits • Practical strategies to reduce ultra-processed foods, handle picky eating, and support issues like eczema at the root You don’t need to do everything perfectly to transform your child’s health. Small, consistent shifts—what’s on

Most of medicine is built around snapshots. You feel something, you test for it, and by the time you find it, you’re already behind. But what if the problem isn’t the test—it’s how we use it? In this episode, I sit down with physicist and imaging pioneer Dr. Daniel Sodickson, Chief Medical Scientist at Function Health and author of The Future of Seeing. We break down why tools like MRI are shifting from one-time scans to something far more powerful: tracking your health over time. Watch the full conversation on YouTube, or listen wherever you get your podcasts. In this episode, we cover: • Why waiting for symptoms puts you behind—and how to get ahead • What an MRI can reveal about your body that bloodwork can’t • How tracking your health over time helps you catch problems sooner • Why having a baseline could change the way you make health decisions • What it means to shift from reacting to disease to actually predicting it When you stop looking at a single result and start looking at patterns, you c

Sleep is one of the most important and most overlooked drivers of your health. If you’re struggling to fall asleep, waking up at 2–4am, or getting a full night’s sleep but still feeling exhausted, your body is trying to tell you something. Poor sleep isn’t just about habits, it’s a signal that key systems like your nervous system, blood sugar, hormones, or circadian rhythm are out of sync. In this episode, we break down what’s actually disrupting your sleep and how to fix it at the root. Here’s what you’ll understand: • Why sleep issues are rarely just one problem and how stress, blood sugar, and circadian rhythm all interact • The real reasons you can’t fall asleep, wake up in the middle of the night, or feel tired despite 7–8 hours • What actually helps (and what doesn’t)—from magnesium and melatonin to nervous system regulation • The 5 core pillars of better sleep and the highest-impact changes you can start tonight Sleep isn’t something you force, it’s something that happens when your body feels safe,

What if feeling better didn’t have to take months or years to figure out, but could start today? On this episode of The Dr. Hyman Show, I sit down with Dr. Scott Sherr to talk about why so many people feel stuck in what he calls a “sympathetic spiral of doom.” Energy is low, recovery isn’t what it used to be, and there’s a constant sense of stress that doesn’t seem to resolve. We walk through what’s actually happening beneath the surface, why it can be so hard to break out of that pattern once you’re in it, and how to start shifting your energy and recovery. Watch the full conversation on YouTube, or listen wherever you get your podcasts. In this episode, we discuss: • Why you feel “tired but wired” and what it actually means for your body • What’s keeping your energy low even when nothing obvious is wrong • How stress from your life and environment builds up and keeps you stuck • Why calming down doesn’t always work—and what to focus on instead • How to start rebuilding your energy so your body can

If you’re doing everything “right”—eating well, taking supplements, working on your health—but still feel stuck, this might be the missing piece. Your body cannot heal if it thinks it’s under threat. In this episode, we unpack why your nervous system may be the hidden driver behind inflammation, hormone imbalance, weight gain, and more—and how to finally shift your body into healing mode. Here’s what could be keeping you stuck: • Why chronic stress and nervous system dysregulation can block healing—even when everything else is “on point” • How your nervous system impacts your gut, hormones, metabolism, immune system, and weight • The difference between feeling “tired but wired” vs. true resilience and what a regulated system actually looks like • Simple, science-backed ways to regulate your nervous system through blood sugar, breath, sleep, and daily habits You can’t out-supplement or out-diet a body that feels unsafe. But when you learn how to regulate your nervous system, you unlock your body’s natural ab

Longevity isn’t just about talent—it’s about what you’re willing to change when your body starts asking for something different. On this episode of The Dr. Hyman Show, I’m joined by Chris Paul—one of the most respected point guards of all time—to talk about the mindset that’s carried him through more than two decades in the NBA. We get into what shifted along the way and what it really takes to keep showing up at a high level year after year. Watch the full conversation on YouTube, or listen wherever you get your podcasts. Here’s what we cover: • Why what worked in your 20s stops working and what to do instead • How inflammation shows up and what improves when you address it • Why stress and poor sleep quietly drain energy and slow recovery • What simple habits actually move the needle over time • How understanding your data helps you make better daily decisions Your body is always giving you signals. The earlier you begin to listen and respond, the more it can support you over time. View Show Notes

Seasonal allergies aren’t just about pollen—and if you’re only treating symptoms, you’re missing the real problem. What if your allergies are actually a sign that your immune system is out of balance? In this episode, we break down what’s really driving allergy symptoms and what you can do now to calm your immune system at the root. Here’s what you need to know before this allergy season gets worse: • Why allergies are a sign of immune dysfunction—not just a reaction to pollen • The hidden role of gut health, inflammation, and your microbiome in driving symptoms • Key nutrient deficiencies and environmental exposures that make allergies worse • A functional medicine approach to reducing symptoms naturally by restoring balance and not just blocking histamine You don’t have to suffer through allergy season every year. When you address the root causes, you can retrain your immune system, reduce your reactivity, and build long-term resilience. Visit ⁠functionhealth.com for 160+ lab tests at just $365 a year.

Breast implants may have become increasingly common—but for some women, the experience doesn’t always unfold the way they expected. On this episode of The Dr. Hyman Show, I sit down with Dr. Jonathan Kanevsky, a board-certified plastic surgeon who made the decision to stop performing breast implant procedures after years of listening closely to his patients. We explore what he started seeing, how to approach this decision, and what alternatives are now available. Watch the full conversation on YouTube, or listen wherever you get your podcasts. You’ll learn: • How to tell if your symptoms may be connected to breast implants • What to consider before deciding to remove them • Why recovery after explant looks different for everyone • What safer, more natural alternatives are available today • How to support your body before and after surgery for better recovery This is a complex and deeply personal decision. My hope is that understanding the full picture helps you make a more informed one. View Show No

Endometriosis affects 1 in 10 women yet it often takes years to diagnose, and many are told their pain is “normal” or simply treated with birth control or surgery. But endometriosis isn’t just a hormone issue—it’s a whole-body condition driven by inflammation, immune dysfunction, gut health, and environmental exposures. In this episode, we break down what’s really causing it and what you can do to address it at the root. I’m joined by my longtime colleague and friend, Dr. Elizabeth Boham, Medical Director and Functional Medicine Physician at The UltraWellness Center. Here’s what we break down: • Why endometriosis is not just a gynecologic condition and the root causes most doctors miss • The hidden role of gut health, inflammation, and the microbiome in driving symptoms • How estrogen imbalance and environmental toxins (xenoestrogens) fuel the condition • A functional medicine approach to reducing pain and preventing recurrence beyond medication or surgery If you’re struggling with endometriosis or unreso

Pregnancy is often filled with anticipation, excitement, and a lot of questions. But biologically, it’s also a powerful window when a baby’s metabolism and long-term health begin to take shape. On this episode of The Dr. Hyman Show, I talk with biochemist and bestselling author Jessie Inchauspé about how nutrition during pregnancy can influence a baby’s development and long-term health. Her new book, 9 Months That Count Forever, takes a closer look at the science behind these connections. Watch the full conversation on YouTube, or listen wherever you get your podcasts. We discuss: • Why pregnancy may be one of the most important windows for shaping lifelong health • Why balancing blood sugar during pregnancy matters—and simple ways to reduce glucose spikes • The nutrients that matter most during pregnancy, from choline and protein to omega-3s • How to make healthier choices during pregnancy without added stress or confusion This isn’t about being perfect. It’s about understanding what matters most and

Fiber is having a moment—but more isn’t always better. From “fiber maxing” trends to high-fiber hacks promising weight loss and better metabolism, it’s easy to assume that piling on more fiber is the answer. In this episode of Office Hours, I break down what fiber actually does in the body, who benefits most from increasing it, and how to use it strategically to support your gut and metabolic health. In this episode, I break down: • What fiber actually does in the body—from feeding your microbiome to regulating blood sugar, cholesterol, and hormones • Who benefits most from increasing fiber (and why it can support weight loss, insulin sensitivity, and estrogen balance) • When more fiber can make things worse—especially with IBS, SIBO, or gut inflammation • How to increase fiber the right way, including types of fiber, timing, hydration, and why protein still matters Fiber isn’t a trend or a quick fix—it’s a foundational nutrient. But the goal isn’t to “max out” your intake. It’s to build metabolic and gut r

Falling in love can be easy. Staying connected when conflict and stress show up is where the real work begins. On this episode of The Dr. Hyman Show, I sit down with relationship repair expert Baya Voce to explore why healthy relationships aren’t defined by the absence of conflict, but by the ability to repair and reconnect—and why repair depends as much on nervous system regulation as communication. Watch the full conversation on YouTube or listen wherever you get your podcasts. Here’s what we unpack: • Why conflict isn’t the real problem in relationships—and what actually keeps couples connected • What happens in the body during arguments, and why nervous system regulation matters more than the “right” words • How past relationship wounds and attachment patterns shape the way we react during conflict • Practical ways couples can repair after conflict and reconnect more quickly When couples learn how to repair after conflict, even difficult moments can become opportunities for deeper connection and g

Pregnancy doesn’t just change your life—it transforms your entire biology. Hormones shift, metabolism adapts, nutrient needs increase, and your nervous system recalibrates in ways most women are never fully prepared for. And after birth, the postpartum phase can be one of the most overlooked and underserved stages of a woman’s health. In this episode, I answer your most common questions, including: • How to choose the right prenatal vitamins—including why methylated folate matters and the difference between folate and folic acid • Natural ways to manage common pregnancy symptoms like nausea, heartburn, sciatica, and fatigue • Key nutrition strategies during pregnancy to support both mother and baby • What happens during postpartum—from hormone and thyroid shifts to hair loss, immune changes, pelvic floor recovery, and C-section healing Pregnancy and postpartum aren’t separate events—they’re part of a continuous biological transition that affects hormones, metabolism, and overall health. The goal isn’t per

Fertility struggles are often treated as a problem to solve only after they appear. But what if they’re actually a signal from the body that something deeper needs attention? On this episode of The Dr. Hyman Show, I sit down with functional medicine physician Dr. Ann Shippy, author of The Preconception Revolution, to talk about why the months—even years—before conception may shape not only your health, but your future child’s long-term health as well. Watch the full conversation on YouTube or listen wherever you get your podcasts. In this conversation, we explore: • What fertility challenges may be signaling about your health, and why infertility may be the body’s “check engine light” • Why the 3–36 month preconception window can shape fertility, pregnancy outcomes, and your child’s long-term health • How just three weeks of ultra-processed food can change sperm quality, and what that reveals about fertility • What couples can start doing now to improve fertility, from strengthening metabolic health to

Peptides are everywhere right now—touted as tools for weight loss, muscle growth, faster recovery, and even longevity. But what are they actually, and do they live up to the hype? In this episode of Office Hours, I break down the science behind peptides, how they influence the body’s signaling systems, and how to think about them wisely within a functional medicine approach. In this episode, I cover: • How peptides act as signaling molecules that regulate metabolism, repair, appetite, and energy • The major peptide categories people are using today—from GLP-1 medications to growth and longevity peptides • When peptide therapies may be helpful and the situations where caution is important • Why foundational health habits still matter more than any advanced therapy Peptides may represent an exciting frontier in medicine, but they’re not shortcuts. They amplify the biological environment you already have. When your foundation is strong, targeted therapies can enhance healing and performance. But when your biol