The Doctor's Farmacy With Mark Hyman, M.d.

Too often, we focus on treating symptoms without fully understanding the systems underneath them—or the conditions that allow the body to function well in the first place. On this episode of The Dr. Hyman Show, I sit down with Fidji Simo, CEO of Applications at OpenAI, to explore how AI could help us shift medicine from treating symptoms to restoring systems. We talk about why chronic illness is so often misunderstood, how health data has been fragmented across silos, and what becomes possible when we finally see the full picture. Watch the full conversation on YouTube or listen wherever you get your podcasts. In this episode, you’ll learn: • Why having a diagnosis doesn’t always explain what’s actually driving your symptoms • How connecting your labs, lifestyle data, and health history can reveal patterns you might otherwise miss • What it looks like to move from reactive care to proactive, personalized health • How better context can help you make clearer decisions about food, sleep, movement, and r

For decades, we’ve been told that high cholesterol is the main driver of heart disease—and that lowering LDL should be the primary goal. But as science has evolved, so has my thinking. In today’s Office Hours, I explain why cholesterol alone doesn’t tell the full story, what most doctors still aren’t testing, and what’s really driving heart disease for the majority of people. Today we discuss: • Why many people have heart attacks despite “normal” LDL cholesterol • The difference between cholesterol levels and cholesterol particles • How inflammation and insulin resistance fuel heart disease • Why sugar and refined starches are more dangerous than fat • The most important labs to assess real cardiovascular risk • What ApoB, lipoprotein(a), and triglyceride-to-HDL ratio reveal about your health • How metabolic dysfunction—not cholesterol alone—drives plaque buildup Heart disease is far more complex than a single lab value. When you understand the role of metabolic health, inflammation, and the right biomarke

Around the world, we’re seeing declining sperm counts, rising infertility, more erectile dysfunction, and lower testosterone—even in younger men. These trends aren’t just affecting family planning; they’re pointing to something much bigger happening in men’s health. Joining me today on The Dr. Hyman Show is Dr. Michael Eisenberg, a Stanford researcher and leading voice in male reproductive health. We talk about why sperm quality matters far beyond fertility—and how everyday health choices quietly shape it. Watch the full conversation on YouTube or listen wherever you get your podcasts. [YOUTUBE THUMBNAIL] We cover: • Why sperm quality may be one of the strongest early indicators of overall health and longevity • How metabolic dysfunction, belly fat, and low testosterone impact fertility and sexual function • The role environmental toxins and endocrine disruptors play in declining sperm counts • What men can do right now to protect fertility and long-term vitality When we look at fertility through the

What’s Really Driving Infertility—and What You Can Do About It Fertility struggles are far more common than most people realize—and far more complex than we’re often told. Today I answer listener-submitted questions on fertility, hormone balance, and preparing your body for conception. Here’s what I cover: • Why infertility is rising and what’s really driving it • The hidden role of blood sugar, inflammation, and toxins in hormone balance • What to do if labs are “normal” but fertility struggles persist • How lifestyle and nutrition improve egg and sperm quality • Simple, practical steps to support fertility now and long-term Fertility challenges are complex and often influenced by underlying imbalances. Addressing root causes can help support your body’s natural resilience over time. Visit ⁠functionhealth.com⁠ for 160+ lab tests at just $365 a year. Helpful Resources: Grab Our FREE Fertility Blueprint: 7 Daily Practices That Support Conception https://drhyman.com/products/fertility-blueprint?_pos=1&_psq

On this episode of The Dr. Hyman Show, I sit down with Dr. Robert Hedaya, a psychiatrist who has spent decades working at the intersection of biology, brain function, and mental health. His approach starts with a different question than most psychiatry asks: what’s interfering with the brain’s ability to regulate, adapt, and repair itself? We talk about why many mental health diagnoses describe symptoms without explaining causes—and how measuring brain function, energy, and network activity is opening the door to more precise, individualized care. Watch the full conversation on YouTube or listen wherever you get your podcasts. [YOUTUBE THUMBNAIL] We discuss: • How biological imbalances can drive anxiety, depression, and cognitive symptoms • Why many “treatment-resistant” mental health issues have overlooked root causes • How brain energy and mitochondrial function influence mood and cognition • What advanced brain mapping reveals about how your brain is actually working For far too long, mental healt

In this Office Hours episode, I break down what the government finally got right about food, where the new guidelines still fall short, and—most importantly—how to apply them in real life without confusion or overwhelm. For the first time in decades, there’s meaningful progress: a recognition that ultra-processed foods are harming us, that protein matters for optimal health, and that nutrition isn’t one-size-fits-all. But there’s still work to do. In this episode, I break down: • Why calling out ultra-processed foods is the most important—and historic—shift in the new guidelines • What the new protein recommendations actually mean for everyday people • Why the low-fat era is finally ending—and why whole foods matter more than isolated nutrients • Where the guidelines still fall short, including saturated fat limits, whole grain recommendations, and lack of personalization • How to apply the guidelines to kids and families without perfection or overwhelm • Why chronic disease is a policy problem—not a persona

Longevity isn’t just about what you eat or how you train—it’s really more about whether you believe your body is worth investing in. On this episode of The Dr. Hyman Show, I’m joined by my longtime friend and colleague Dr. Gabrielle Lyon to explore why muscle may be one of the most overlooked drivers of long-term health. We focus on practical, accessible ways to build strength as you age, and why muscle plays a much bigger role in your health than most people realize. We explore: • How strength training supports your blood sugar and metabolic health, beyond what the scale can show • Why muscle quality—not weight—is a stronger predictor of long-term health • How building strength helps you stay mobile, capable, and resilient as you age • What most people miss about protein and muscle health Aging well is something you can actively support, starting with how you care for your body today. And strength is one of the most powerful places you can begin. View Show Notes From This Episode Get Free Weekly He

What Should I Actually Eat? Diet confusion is everywhere. But the truth is, there’s no one-size-fits-all diet. The best diet is the one that works for your biology. In this Office Hours episode, I answer your most common diet questions and break down the core principles everyone should understand before choosing how to eat. In this episode I break down: • Why the “best diet” is personalized—and why ideology should never override biology • The universal principles everyone should follow, regardless of diet • Why ultra-processed foods—not carbs, fat, or protein—are the real problem • How blood sugar dysregulation drives chronic disease, including mental health issues • Keto, paleo, vegan, and Mediterranean: who they help, common mistakes, and what to watch for • How to tell if your diet is working—using symptoms, energy, digestion, mood, and labs Your body is the smartest doctor in the room. The key is learning how to listen. Visit ⁠functionhealth.com⁠ for 160+ lab tests at just $365 a year. Helpful Resou

On this episode of The Dr. Hyman Show, I’m rejoined by psychiatrist and Harvard professor Dr. Chris Palmer for a conversation that challenges how we’ve been taught to think about mental illness. For decades, psychiatry has focused on managing symptoms—often without asking what’s actually driving them. We discuss a different way of understanding mental health, one that looks beyond diagnostic labels and considers how whole-body biology influences brain function, resilience, and recovery.  Watch the full conversation on YouTube or listen wherever you get your podcasts. In this conversation, we explore: • Why mental illness is rising alongside obesity, diabetes, and other chronic diseases • How whole-body biology influences mood, focus, and emotional resilience • The link between inflammation, metabolic dysfunction, and conditions like depression and bipolar disorder • How nutrition, testing, and lifestyle changes can support real recovery If mental health has ever felt close to home for you or someone

Most of us don’t realize how much alcohol affects our bodies until we take a break. In this first episode of Office Hours, I break down what really happens when you give up alcohol for 30 days. Alcohol impacts nearly every system—from your brain and hormones to your gut, liver, and immune system—but the good news is your body begins repairing itself far faster than most people expect. I discuss: • What alcohol really is—and why the “buzz” is actually your brain slowing down • How alcohol affects neurotransmitters like GABA, dopamine, and glutamate • Why even moderate drinking disrupts sleep, mood, hormones, and metabolism • How alcohol impacts the liver, gut microbiome, immune system, and cancer risk • Why hangovers feel like the flu—and what’s actually happening in your body • What happens when you stop drinking, week by week, from detox to deep repair • The surprising benefits to energy, focus, skin, sleep, and emotional resilience • Practical tools to manage cravings, social pressure, and sleep di

This week, in another holiday edition of The Dr. Hyman Show, I’m highlighting a conversation with Dr. Rhonda Patrick, a leading expert in nutritional science and aging — a discussion that still feels incredibly important today. We dig into how hidden micronutrient deficiencies can influence metabolism, mood, longevity, and long-term health. Here’s to supporting our health in the year ahead. In this episode, you’ll learn: • Why vitamin D is essential for longevity, immune health, and mood • How magnesium influences metabolism, blood sugar, and brain function • Why even “healthy” diets can leave us undernourished • What it takes to test and personalize your micronutrient intake Better aging starts by giving your cells what they’re missing. When your body has the right nutrients, it can repair, renew, and thrive at any stage of life. Here’s to a healthy start to the new year — I’m excited for what we’ll explore together. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman htt

As we wind down for the holiday season, we’ll be taking a short break. But I didn’t want to leave you without something meaningful to explore. So for today’s Monday episode, we’re revisiting one of our most powerful deep-dive topics of 2025.Thank you for being part of this community. We’ll be back in the new year with brand-new episodes and I truly can’t wait to share what’s coming next. In today’s episode, we feature four segments about hitting the reset button on our diet and lifestyle choices and establishing new behaviors for our overall wellbeing. We all get off track sometimes. Life gets busy, we indulge a little too much during the holidays, or we ignore the messages our body is sending us to sleep more and eat better. This can leave us feeling super sluggish, run-down, or unable to think clearly. This is what I call FLC syndrome? It’s when you feel like crap!  This episode is brought to you by BIOptimizers. Head to ⁠⁠bioptimizers.com/hyman⁠⁠ and use code HYMAN to save 15%. Full-length episodes

This week, in a special holiday edition of The Dr. Hyman Show, I’m revisiting a powerful conversation with Dr. Aseem Malhotra, a leading cardiologist and advocate for ethical, evidence-based medicine, where we unpacked the uncomfortable truths about cholesterol, statins, and what really drives heart disease. Wishing you a peaceful holiday week. We unpack: • Why LDL cholesterol isn’t the whole story when it comes to heart disease • How reducing inflammation and insulin resistance can better protect your heart • What statins can—and can’t—do to improve real cardiovascular outcomes • How industry influence shapes the prescriptions patients receive Better heart health starts with better information and real progress begins when we stop treating numbers and start treating what’s actually causing disease. Hope you have a peaceful holiday week. I look forward to continuing this journey together in the new year. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.co

As we wind down for the holiday season, we’ll be taking a short break. But I didn’t want to leave you without something meaningful to explore. So for today’s Monday episode, we’re revisiting one of our most powerful deep-dive topics of 2025.Thank you for being part of this community. We’ll be back in the new year with brand-new episodes and I truly can’t wait to share what’s coming next Did you know that sugar is lurking in more places than you might think, and it could be sabotaging your health in ways you never imagined? In this episode, I look back on my conversations with Dr. Richard Johnson and Dr. Robert Lustig. We examine how certain foods, especially those loaded with sugar, can trigger overeating, disrupt your metabolism, and lead to a cascade of health issues. Plus, I'll share practical strategies for detoxing from sugar, managing blood sugar levels, and reclaiming your health. ⁠This episode is brought to you by BIOptimizers. Head to ⁠bioptimizers.com/hyman⁠ and use code HYMAN to save 15%. Ful

Wellness can feel complicated, but most of what matters for long, healthy living is surprisingly simple. In this episode of The Dr. Hyman Show, I sit down with my longtime friend Dr. Ezekiel “Zeke” Emanuel—oncologist, bioethicist, and author of Eat Your Ice Cream—to explore six core principles that support longevity, from food and movement to social connection and purpose. Zeke shares what we’re getting wrong about wellness, why community matters more than we think, and how small choices can reshape both our health and our healthcare system. Watch the full conversation on YouTube or listen wherever you get your podcasts. We discuss: • Why simple habits outperform extreme biohacks—and how to build them into daily life • How social connection protects your health as powerfully as diet and exercise • What to eat for longevity without tracking, restricting, or following trends • How movement, strength, and flexibility each support long-term health and function • What actually improves sleep when you can’t

Ready to feel better than you ever have? Here are five ways to your best health in 2026—simple shifts that work faster than most people realize: food as medicine, restorative sleep, stress mastery, daily movement, and periodic detox resets. Eating real, whole foods sends powerful healing signals to your gut, hormones, and genes, while avoiding processed foods removes the biggest drivers of inflammation. Quality sleep and stress-lowering practices help rebalance cortisol so you can think clearly, feel calmer, and have steady energy throughout the day. Moving your body strengthens your metabolism, protects your brain, and keeps you functional as you age. And short detox periods that remove sugar and processed foods while adding nutrient-dense meals can reboot your entire system and show you just how good “normal” is supposed to feel. When you bring these five pillars together you create momentum that touches every part of your life. In this episode, I highlight how five simple foundations—food, sleep, stress

Every parent wants to feed their baby well—but finding clarity in today’s system isn’t always easy. In this episode of The Dr. Hyman Show, I sit down with Laura Modi, CEO and co-founder of Bobbie, to talk about the real challenges families face when it comes to feeding and why it so often feels overwhelming.  Laura shares her personal journey, the moments that changed everything, and what she’s learned from supporting thousands of parents through this stage. Enjoy the full conversation on YouTube or listen wherever you get your podcasts. In this episode, you’ll learn: • Why shame shows up so quickly around feeding—and how to replace it with clarity and confidence • How to navigate breastfeeding challenges without feeling like you’re “failing” • What most parents don’t realize about formula standards, labels, and ingredient quality • How combo feeding can ease pressure, support mental health, and support your baby’s development • Why America’s fragile formula system matters for every family and how to s

Imagine a small town where neighbors gather for every celebration, and people stay remarkably healthy simply because they’re deeply connected. Research shows that meaningful relationships—not achievement, diet, or even exercise—are the strongest predictor of long-term health and happiness, while loneliness can be as harmful as smoking two packs a day. Our social bonds influence gene expression, lowering stress and inflammation and activating the body’s natural healing pathways. By prioritizing kindness, investing in uplifting relationships, and creating simple moments of togetherness, we tap into one of the most powerful longevity tools we have. And the hopeful truth is that building just a few authentic connections can change your life in profound, measurable ways. In this episode, I discuss, along with Radha Agrawal and Jeff Rosenthal, why deep, authentic connection is one of the most powerful determinants of our physical health, happiness, and longevity. Radha Agrawal is the co-founder, CEO, and Chie

On this episode of The Dr. Hyman Show, I’m joined by Maria Menounos, journalist, actor, and founder of Heal Squad, to explore what it truly means to take ownership of your health. After years of pushing through nonstop stress and serious health challenges, Maria discovered that real healing starts with mindset, community, and self-advocacy. Watch the full conversation on YouTube or listen wherever you get your podcasts. We discuss: • How you can recognize early warning signs and take action before they become bigger health issues • Why small rituals can make wellness social, joyful, and sustainable • Tools to build a team that truly supports your healing • Simple mindset practices to reframe fear and find strength through uncertainty • The daily choices that help you move from survival mode to genuine healing Maria’s story is a reminder to us all that healing starts with paying attention to your body, your thoughts and the community you choose to surround yourself with. View Show Notes From This Episo

Many people experience a deep, lingering fatigue that isn’t fixed by a full night’s sleep, and it often stems from real imbalances inside the body. When mitochondria—the tiny engines that power our cells—are stressed by poor diet, toxins, infections, or lack of rest, the whole system can slow down. Ongoing stress can also disrupt the adrenal system, leaving some people feeling wired and anxious while others feel drained from morning to night. The encouraging news is that steady habits like nourishing whole foods, balanced blood sugar, restorative sleep, and gentle movement can help the body find its rhythm again. With the right support, energy often returns, and a sense of hope does, too. In this episode, I dive into, along with Dr. Izabella Wentz and Dr. Elizabeth Boham, the real roots of chronic fatigue, showing how stress, lifestyle, and hidden imbalances drain our energy—and how practical, nourishing habits can help restore it. Izabella Wentz is an internationally acclaimed thyroid specialist and a lice