High Intensity Health Radio With Mike Mutzel

Alan Green, MD has been using low-dose rapamycin in his clinical practice for years. We discuss the many potential health benefits and ways this compound can be used as a tool to support healthspan and prevent age-associated diseases.  Sponsored Message: Support your Intermittent Fasting lifestyle with the updated Berberine HCl Fasting Accelerator by MYOXCIENCE: https://bit.ly/berberine-fasting-accelerator Use code podcast to save 12% Full Video Interview:  https://bit.ly/3U5S0OQ Show Notes:  05:05 Rapamycin stops this deterioration and the development of dementia. 09:47 Pharmaceuticals do not treat end-stage disease.  11:15 Rapamycin is anti-mTOR. mTOR is involved in all age-related diseases.  19:35 Evolution’s way to promote new gene variations is to eliminate those with old variations with a short lifespan. 24:40 Ageing is a programed genetic timebomb. 30:50 Slowing mTOR with rapamycin slows ageing. 37:40 Transplant patients do not get the age/health benefits because the dosing of rapamycin is too high. 

Low muscle mass is higher than expected in people recently diagnosed with cancer and cardiovascular disease. Resistance exercise and nutrition may help prevent these chronic diseases. Support your Workout Sessions and Healthy Hydration with this Creatine Electrolyte Combo by MYOXCIENCE: http://bit.ly/electrolyte-stix Save 12% with code podcast at checkout Link to research & images: https://bit.ly/3ZH5Ok1 References:   Morlino, D. et al. Prevalence of Sarcopenia in Women with Breast Cancer. Nutrients 14, 1839 (2022). Jeznach-Steinhagen, A. et al. Higher Muscle Mass and Higher Serum Prealbumin Levels Are Associated with Better Survival in Hemodialysis Patients during a Five-Year Observation Period. Nutrients 15, 1237 (2023).   Key Takeaways: 00:36 Muscle enhances survivability from chronic disease. 01:10 There was a significant survival benefit from higher quantities of muscle. In chronic kidney disease. 02:00 Resistance training enhances longevity and prevents a variety of disease states. 02:10 Independe

Deaths in children have increased 20% as a result of lockdowns and so called safety measures 'to flatten the curve. Support your Intermittent Fasting lifestyle with the updated Berberine Fasting Accelerator by MYOXCIENCE: Use code podcast to save 12% Video and Show Notes: https://bit.ly/3JqFft4 References: Woolf SH, Wolf ER, Rivara FP. The New Crisis of Increasing All-Cause Mortality in US Children and Adolescents. JAMA. Published online March 13, 2023. doi:10.1001/jama.2023.3517 Time Stamps: 00:21 There has been a dramatic increase in the death rate of children and adolescents. 01:45 COVID had little to do with the surge in death rates. 02:30 An increase of nearly 20% in all-cause mortality for children ages 1 to 19 years old between has taken place between 2019 and 2022. 03:30 All cause mortality for children 9 and under increased in 2021 by 8.4%. 04:10 Significantly more children died from suicide, homicide, overdoses, and injuries, than died from COVID. 06:45 Injury mortality for ages 10 to 19 rose 22.6%

A new study found daily intermittent fasting for ~ 17-19 hours was sufficient to enhance fat loss, metabolic health and bio-markers linked longevity as well as cancer prevention.  Support your Intermittent Fasting lifestyle with the updated Berberine HCl Fasting Accelerator by MYOXCIENCE: Use code podcast to save 12% Link to study, show notes: https://bit.ly/3JqFft4 Time Stamps:   00:00 Fasting 17 to 19 hours per day for 30 days increased autophagy and increased tumor suppressor P53. 02:10 Autophagy increased, favorable changes were made in the inflammasome hub, and there was a decrease in senescence-associated-signaling molecules. 03:00 P53 helps repair DNA damage, prevents senescence, and contributes to reduced atherogenic risk. 06:05 Autophagy has tissue-specific benefits, especially in the liver and brain. 07:35 Regular exercisers have a great increase in fasted-associated autophagy initiation proteins. 08:35 Long duration fasts can catabolize lean mass, possibly increasing risk for cardiovascular disease

After years of demonizing dietary cholesterol, the consensus in the medical community is finally shifting: cholesterol-rich foods have a minimal impact on serum LDL or total cholesterol. Support your Intermittent Fasting lifestyle with the updated Berberine HCl Fasting Accelerator  by MYOXCIENCE: https://bit.ly/berberine-fasting-accelerator Use code podcast at checkout to save Link to research and video: https://bit.ly/3TlMQ0J ---------------------------Show Notes----------------------- 0:00 Intro 1:10 Insulin regulates the enzyme that synthesizes endogenous cholesterol.  1:50 Dietary cholesterol does not have a significant impact on serum cholesterol.  2:45 Carbohydrates increase LDL and total cholesterol and insulin. 3:30 Cholesterol has powerful benefits.  5:00 Low cholesterol diets can increase endogenous production of cholesterol and the expression of LDL receptors.  5:40 High cholesterol diet expresses fewer LDL receptors.  8:00 Eggs and meat consumption has a minimal impact on serum cholesterol.  8:53

Let's discuss how how different macronutrients and blood sugar issues can regulate aging and the induction of cellular senescence. We also discuss how various dietary interventions can achieve prevention of disease and extension of lifespan by modulating senescence. Sponsored Message: Support your Intermittent Fasting lifestyle with the updated Berberine HCl Fasting Accelerator by MYOXCIENCE: Use code podcast to save 12% Link to Articles & Images: https://bit.ly/42kjEen Show Notes: 00:25 Cellular senescence accelerates biologic ageing. 02:00 Senescent cells are enlarged, have dysfunctional mitochondria, and release pro-inflammatory signaling molecules. 02:30 Senescence manifests as wrinkles, memory loss, muscle loss, gray hair, fatty liver, excessive visceral adipose tissue. 03:45 Senescence occurs in response to stressors or developmental signals and behave similar to cancer cells. 05:45 Dysfunctional mitochondria influences glycolysis in cells. 06:15 Give your cells less fuel, glucose, for the prolifer

Several new studies find NAC and Glycine combinations can support biologic aging and more. Let's dive into these details. Sponsored Message: Support glutathione synthesis and detoxification of environmental pollutants* with NAC Glycine Supreme from MYOXCIENCE: https://bit.ly/NAC-Glycine-Supreme Save with code podcast at checkout:  Studies and detailed show notes: https://bit.ly/41YvaMv Episode Time Stamps 00:00 Glutathione is one of your body’s most important antioxidant and detox molecules. 00:30 Supplement with raw materials, instead of directly supplementing with glutathione. 01:00 N-acetylcysteine and glycine are rate limiting amino acids in glutathione production. 01:00 Glutathione is comprised of glutamine, cystine, and glycine. 02:40 Glycine-NAC supplementation improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, ageing hallmarks, metabolic defects, muscle strength, cognitive decline and body composition. 05:20 Taking direct antioxidants has conflicting evidence

According to the media, erythritol purportedly causes heart attacks. In actuality, metabolically unhealthy people convert glucose to erythritol. Here's the details about high blood levels of erythritol and heart disease.  Support your Intermittent Fasting lifestyle with the updated Berberine Fasting Accelerator by MYOXCIENCE: https://bit.ly/berberine-fasting-accelerator Use code podcast to save 12% Link to Studies Mentioned: https://bit.ly/Erythritol-study-breakdown

Courtney Swan, MS shares tips to create a toxin-free home that supports hormonal health and more.  Support your body's Glutathione Synthesis* with the new NAC + Glycine Supreme: https://bit.ly/NAC-Glycine-Supreme Save with code podcast at checkout  Save on the best Non-Toxic Cleaning Products: https://blueland.sjv.io/DVjWkj Show Notes 0:00 Intro 4:30 Forever chemicals wreak havoc on your endocrine system.  6:28 Products applied directly to your skin go into your bloodstream.  6:35 The fact that something is on the shelf at the store does not mean that it is safe.  7:40 Women are exposed to 160 different chemicals daily. 8:40 Obesogens are chemicals stored in your fat which disrupt your hormones that directly impact your metabolism.  9:40 Courtney likes clean cosmetic brands: ILIA, Kosas, Tower 28, and RMS.  15:00 Many food additives we use are banned in other countries.  18:00 BPA chemicals found in plastic cause your body to make more estrogen in both males and females.  19:35 Food and beverage packaging oft

Let's discuss more about cancer, sugar and The Warburg effect.  Support your Workout Sessions and Healthy Hydration with the Electrolyte + Creatine Combo by MYOXCIENCE : https://bit.ly/electrolyte-stix  Use code podcast to save 12% Link to study & Images: https://youtu.be/I6_QmMuluiE Show Notes:  0:00 Intro 0:05 Breast, lung, colon, and brain cancer have been linked with deranged cellular metabolism.  0:27 Cancer is the second leading cause of mortality in the US.  1:00 Normal cells aerobically breakdown carbohydrates and fats to create ATP. 1:50 Cancer cells, in the presence of oxygen, ferment glucose to make pyruvate and lactate.  3:10 Mitochondria regulate preprogrammed cell death.  5:10 Dysregulated glucose metabolism fosters a tumor microenvironment that favors expansive growth.  5:35 PET scan is diagnostic imaging tool which uses a radioisotope glucose, fluorodeoxyglucose, that helps to diagnose cancer. 7:00 Metformin, which decreases glucose, is being used in cancer treatment and therapeutics. 9:10

A new study finds muscle loss raises risk of a heart attack some 281% over a 5 year period--highlighting the importance of muscle and strength training with age.  Support your Workout Sessions and Healthy Hydration with the Electrolyte + Creatine Combo by MYOXCIENCE : https://bit.ly/electrolyte-stix  Use code podcast to save 12% Link to study: https://bit.ly/3IoPkq0

We can prevent 500 million new cases of major chronic diseases in the next 8 years by incentivizing exercise and physical activity. Support your Workout Sessions and Healthy Hydration with the Electrolyte + Creatine Combo by MYOXCIENCE : https://bit.ly/electrolyte-stix  Use code podcast to save 12% Video and Images: https://highintensityhealth.com/ignoring-exercise-will-claim-500m-lives-in-the-next-8-years-study-finds/ Link to study: https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00464-8/fulltext Belly Fat Effect Book: https://amzn.to/3kBkySA

A new analysis finds the death rate (IFR) is 0.03% which is much, much lower than media and experts claimed.  Support your fasting lifestyle with Berberine HCl & Alpha Lipoic Acid by by MYOXCIENCE Nutrition:  https://bit.ly/berberine-biotin-ala-stack Use code Podcast to save Link to Video and Images: https://youtu.be/bhFn3kX6cdE Links to NEW Stanford Study: https://www.sciencedirect.com/science/article/pii/S001393512201982X

A damning new investigation finds the Academy of Nutrition and Dietetics takes money from, and invests in, food companies that make processed-food products that are harmful to your health, documents show. Support your Workout Sessions with the Creatine Electrolyte Combo by MYOXCIENCE: bit.ly/electrolyte-stix Save 15% with code podcast at checkout Link to Video and Research: https://bit.ly/3DyWK8A Show Notes: 00:00 86% of authors or co-authors have financial ties to pharmaceutical companies when drug trials are reported. 01:31 About 30% of the revenue of the Academy of Nutrition and Dietetics, which certifies over 100,000 dietitians, comes from major big food and pharmaceutical companies. 03:10 The FDA, CDC, and NIH receive industry funding and hire from the industry they regulate. 04:00 About 67% of calories consumed by children are processed foods. 05:10 Adults eat 57% of calories from processed foods. 05:30 The association that makes dietary guidelines has stock in food companies and creates favorable rese

Dr. Gabrielle Lyon discusses protein requirements needed to maintain healthy muscle as you age and the latest research about muscle science. Sponsored: Support your Workout Sessions and Healthy Hydration with this Creatine Electrolyte Combo by MYOXCIENCE Save 15% with code podcast at MYOXCIENCE.com Link to Video and Show Notes: https://bit.ly/3XQrvxQ Key Takeaways: 0:00 Intro 2:20 Dietary protein and muscle are critical factors in longevity and ageing. 2:55 mTOR’s purpose is growth promotion, not growth initiation. 5:15 Your ability to survive cancer is directly related to muscle. 10:50 Higher IGF-1 is linked with lower all-cause mortality. 14:15 RDA protein recommendation has not changed in 30 years. 15:30 Dr. Lyon recommends 1.6 grams/kilogram, or 1 gram per pound ideal body weight daily. 16:30 The capacity to store protein, other than amino acid reservoir in our muscles, does not exist. 18:10 You should not be doing fasting or protein restriction when you are in your 60s. 20:05 We have no consistent way t

Semaglutide aka Ozempic is a GLP-1 agonist that's been around for a long time, suddenly Hollywood elites are now promoting it for fat loss. Here's the science you need to know. Sponsored: Support your Workout Sessions and Healthy Hydration with this Creatine Electrolyte Combo by MYOXCIENCE Save 15% with code podcast at checkout Video and Images: https://bit.ly/3wpnpAE Research Mentioned: Wilding, J. P. H. et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. New Engl J Med 384, 989–1002 (2021). Sharma, D., Verma, S., Vaidya, S., Kalia, K. & Tiwari, V. Recent updates on GLP-1 agonists: Current advancements & challenges. Biomed Pharmacother 108, 952–962 (2018). Show Notes: 0:20 Semiglutide is a GLP-1 agonist. 00:30 GLP-1, glucagon like peptide 1, functions under the category of gastrointestinal incretin hormones that helps you process the foods you eat. It improves insulin sensitivity. Decreases glucagon. 01:30 About 80% of the mechanisms of bariatric surgery is by amplifying the release

Louisa Nicola is a neurophysiologist and brain coach for many professional athletes and Wall Street execs. She discusses science-based tools and strategies to boost brain health and mental performance. Support your Workout Sessions and Healthy Hydration with this Creatine Electrolyte Combo by MYOXCIENCE Save 15% with code podcast at checkout Link to the Video Interview: https://bit.ly/3R7noel Connect with Louisa: https://www.neuroathletics.com.au Show Notes: 03:10 Louisa was elite triathlete when she realized the impact the brain had on all aspects of performance. She and her fellow athletes were not taught about sleep or nutrition. 04:20 The nervous system must be optimized to optimize performance throughout the body and as a person. 05:35 We used to sleep about 12 hours a day in prehistoric times. Sleep regenerates our brains. 06:20 There are 4 stages of sleep. Stage one is as you are falling asleep. Stage 2 is light sleep. Stage 3 is deep sleep/slow wave sleep/non-REM sleep. Stage 4 is REM sleep. Stages 3

A new study found cardio primes leg your muscles, enhancing the benefits of resistance training. Sponsored: Support your Exercise Sessions and Healthy Hydration Creatine with the Electrolyte Combo by MYOXCIENCE: http://bit.ly/electrolyte-stix Save 15% with code podcast at checkout Link to Research, Video, Images and More: https://bit.ly/3W7S7IU Key Time Stamps: 0:05 Cardio helps with muscle hypertrophy by from resistance training by increasing capillary density in the muscle 0:44 Cardio (aerobic conditioning) didn’t interfere with hypertrophy from resistance training, it actually enhanced it 1:15 Capillary density increases from cardio help with muscular hypertrophy from resistance training 2:47 Most import quote to hear from the study 3:30 How to conceptualize pairing cardio with resistance training during your workout sessions

The American Academy of Pediatrics published new guidelines, now recommending gastric bypass surgery and pharmaceutical weight loss drugs for young children to help address the childhood obesity epidemic. Sponsored: Support your Workout Sessions and Healthy Hydration Creatine Electrolyte Combo by MYOXCIENCE Save 15% with code podcast at checkout Link to Research and Show Notes: https://bit.ly/3CIIUjr

Creatine is an essential nutrient. New research highlights how creatine is involved in a range of processes linked with heart, brain and muscle health. Support your Workout Sessions and Healthy Hydration with the unique Creatine Electrolyte Stix Combo by MYOXCIENCE : https://bit.ly/electrolyte-stix Use code podcast to save 15% Link to research: https://bit.ly/creatine-for-health Time Stamps: 00:00 Creatine is a conditionally essential nutrient for children and adults of all ages. 00:20 Electrolytes help enhance the absorption of creatine through the sodium citrate creatine transport protein. 00:40 Creatine is involved in energy synthesis and re-phosphorylation of ATP. 01:10 Creatine is utilized for explosive intense exercise. 01:40 Creatine is conditionally essential for cognitive function, overall health, and heart health. 02:00 Vegans and vegetarians do not get sufficient creatine and may want to consider supplementation. 03:20 Creatine is involved in methylation and the formation of SAMe, and thus may impa