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Why 72 Hours Changes Everything: The Science of Fasting, Autophagy & Cellular Reset

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Sinopsis

About this episode: In this episode of the Thrive with Cate Stillman Podcast, Cate leads a live Club Thrive session recorded mid-fast alongside members deep in their own 72-hour water fast or Fast Mimicking Diet (FMD) cycles — delivering one of the most scientifically rich and practically grounded conversations in the series. Cate walks through a research-backed slide deck — built with AI and Perplexity — that maps exactly what happens inside your liver, cells, and brain from hour zero to hour 72 of a fast. From the sharp insulin drop at hour 12 to the ketogenesis threshold at hour 18, through to peak autophagy and mitochondrial pruning at hours 48 to 72, this session makes the invisible visible. She explains why beta-hydroxybutyrate (BHB) — the primary ketone body produced during fasting — is not just fuel for the brain, but a powerful signaling molecule that regulates gene expression, reduces inflammation, and suppresses appetite. She also presents clinical trial data showing that three FMD cycles can re