Dr. Caroline Leaf Podcast

Ozempic and other GLP-1 medications aren’t just changing bodies. They’re changing brains too. In this episode, I unpack what’s really happening beneath the surface when you take medications like Ozempic, Wegovy, or Mounjaro. Not from a place of hype or fear-mongering, but from curiosity, neuroscience, and compassion. We talk about how GLP-1s influence hunger, motivation, emotional balance, and even your sense of self, and why so many people are surprised by the mental and emotional shifts that come along with physical weight loss. You’ll learn: How GLP-1s interact with dopamine and reward pathways in the brain Why some people experience emotional blunting, reduced motivation, or changes in desire What actually happens when you stop taking them, and why hunger returning isn’t failure, weakness, or a lack of discipline The neuroscience behind craving, self-control, and identity What hunger really does for emotional regulation and psychological resilience And just as important