Dr. Howard Smith Oncall

A nose spray could reverse early Alzheimer’s  Vidcast:  https://www.instagram.com/p/C8qtL3vNsA-/ Alzheimer’s dementia develops as brain cells, neurons, progressively lose the ability to communicate.  That occurs when a complex reaction involving the tau protein depletes the micro-bubbles, technically synaptic vesicles, that carry the neurotransmitters necessary for cell to cell communication.  Now Japanese neurobiologists have discovered a peptide molecule PHDP5 that prevents tau from draining the synaptic vesicle supply.  To deliver this Alzheimer’s neutralizing peptide to the brain, the researchers modified it and packaged it into a nasal spray so it penetrates the thin blood-brain barrier at the roof of the nose.  Using this PHDP5-nasal spray, Alzheimer’s like dementia has been reversed in mice.  The treatment works best for early Alzheimer’s.  It can’t cure the disease, but it delays or halts the cognitive decline.  That is significant and hopefully will hit the clinic…..someday soon. https://www.scienc